Xeloda is a cytostatic drug. The drug is used for the treatment of patients with metastatic or locally advanced breast cancer, including after an ineffective chemotherapy course, which included anthracycline drugs and taxanes, and also if the patient has contraindications to anthracyclines.
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Product information
Xeloda tablets 500 mg №120 are a cytostatic agent. The active component of this drug is capecitabine, a derivative of fluoropyrimidine carbamate. This substance interacts in the tissues of tumors with thymidine phosphorylase, resulting in a cytotoxic effect, and - selective. Thus, the use of Xeloda makes it possible to achieve the necessary clinical response with minimal effect on healthy tissues. At the same time, some analogs of Xeloda, also cytostatics, have a cytostatic effect not selectively, using a tumor and healthy tissue.
Safety information
This drug is used in the treatment of breast cancer, including, and in the presence of metastases, as part of complex therapy - in cases when chemotherapy was not effective. In addition, Xeloda is prescribed for the treatment of colon cancer, stomach cancer and esophagus, as well as colorectal cancer.
This medicine is not prescribed concomitantly with sorivudine and its analogs, as well as patients with renal insufficiency and/or individual sensitivity to capecitabine. It is also not recommended to use the drug for pregnant and lactating women.
Xeloda tablets are taken orally. It is necessary to take the pill no later than 30 minutes after eating. The duration of therapy and the scheme of taking Xeloda is determined by the doctor.
Side effects
When using the drug Xeloda most often (in 10% of cases) noted the development of stomatitis, stool, vomiting, increased drowsiness, asthenia, fatigue and palmar-plantar syndrome.
In addition, it is possible to develop such side effects:
Disorders of appetite, pain in the epigastric and abdominal region, dry mouth mucosa, oral candidiasis, flatulence, colitis, duodenitis, gastritis, esophagitis, gastrointestinal bleeding, dermatitis, erythema, dry skin, alopecia, skin itching, skin and nail pigmentation disorders , Onycholysis, photosensitivity reactions, skin cracks. It is also possible the development of a syndrome similar to radiation dermatitis.
Common side effects: fever, asthenia, pain in the extremities, weight change, back pain, dehydration, myalgia, arthralgia, sleep disorders, paresthesia, headache, peripheral neuropathy, dizziness, encephalopathy, confusion, cerebellar symptoms, depression , Conjunctivitis, taste disorders, lacrimation, dyspnea, sore throat, epistaxis, cough, edema, angina pectoris, myocardial infarction, arrhythmia, heart failure, tachycardia, myocardiopathy, atrial fibrillation, ventricular extrasystoles, sudden death, anemia, pancytopenia, neutropenia .
Ascorbic Acid has an important value for life activity of an organism. Participates in regulation of oxidation-reduction processes, carbohydrate metabolism, blood coagulation, normal permeability of capillaries (of smallest vessels), formations of steroid hormones, synthesis of collagen and procollagen. Increases resistance of an organism to infections. It is prescribed at avitaminosis and hypovitaminosis of C, hemorrhagic diathesis, intoxication and diseases of GIT.
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Antiemetic, which is a specific blocker of dopamine (D2) and serotonin receptors. It has antiemetic effect, eliminates nausea and hiccups. Reduces moving activity of the esophagus, increases the tone of the lower esophageal sphincter, accelerates gastric emptying and the movement of food through the small intestine without causing diarrhea. Stimulates the secretion of prolactin.
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