Jardiance (empagliflozin) is an inhibitor of the sodium-glucose co-transporter 2 (SGLT2) used as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. Jardiance is also indicated to reduce the risk of cardiovascular death in adult patients with type 2 diabetes mellitus and cardiovascular disease.
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Drug uses
JARDIANCE is indicated:
- as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus,
- to reduce the risk of cardiovascular death in adult patients with type 2 diabetes mellitus and established cardiovascular disease.
Limitations Of Use
JARDIANCE is not recommended for patients with type 1 diabetes or for the treatment of diabetic ketoacidosis.
Overdosage
In the event of an overdose with JARDIANCE, contact the Poison Control Center. Employ the usual supportive measures (e.g., remove unabsorbed material from the gastrointestinal tract, employ clinical monitoring, and institute supportive treatment) as dictated by the patient’s clinical status. Removal of empagliflozin by hemodialysis has not been studied.
Storage
Store JARDIANCE at room temperature 68°F to 77°F (20°C to 25°C).
Safety information
Warnings
JARDIANCE causes intravascular volume contraction. Symptomatic hypotension may occur after initiating JARDIANCE particularly in patients with renal impairment, the elderly, in patients with low systolic blood pressure, and in patients on diuretics. Before initiating JARDIANCE, assess for volume contraction and correct volume status if indicated. Monitor for signs and symptoms of hypotension after initiating therapy and increase monitoring in clinical situations where volume contraction is expected.
Disclaimer
The information on this page is not intended to be a substitute for professional medical advice. Do not use this information to diagnose or treat your problem without consulting your doctor.
Side effects
The following important adverse reactions are described below and elsewhere in the labeling:
- Hypotension
- Ketoacidosis
- Acute Kidney Injury and Impairment in Renal Function
- Urosepsis and Pyelonephritis
- Hypoglycemia with Concomitant Use with Insulin and Insulin Secretagogues
- Necrotizing Fasciitis of the Perineum (Fournier's Gangrene)
- Genital Mycotic Infections
- Hypersensitivity Reactions
- Increased Low-Density Lipoprotein Cholesterol (LDL-C)
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