Vastarel - the main substance of the drug is trimetazidine, which is used for the prevention of angina attacks in IHD, as well as in vertigo caused by violations of cerebral circulation, Meniere's disease, noise in the ears. It is believed that the beneficial effect of trimetazidine in myocardial ischemia is mainly associated with its antioxidant and antihypoxic properties and cytoprotective effects on the function of cardiomyocytes.
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Vastarel product description
Vastarel has anti-hypoxic, anti-anginal, anti-ischemic effects on the human body. The composition of this pharmaceutical product includes - trimetazidine, which has an impact on the cellular metabolism, normalizes the energy balance, suppresses the oxidation of fats in the body. It has an antioxidant effect. In case of angina, it lessens the frequency of seizures and reduces the need for nitrates. After 2 weeks of treatment, it leads to an enhancement of the tolerance to physical activity and to the decrease in fluctuations of the blood pressure. Due to an active use of the preparation, the results of vestibular samples and hearing improve, dizziness and noise in the ears diminish. In case of a vascular pathology of the eyes, Vastarel improves the functional state of the retina. It supports normal contractility of the myocardium, prevents intracellular depletion of ATP and creatine phosphate. In conditions of acidosis, it normalizes the state of ion channels of membranes, prevents the accumulation of calcium and sodium in cardiomyocytes, normalizes the intracellular content of potassium ions. Lessens the intracellular acidosis and phosphate content, caused by myocardial ischemia and reperfusion. Prevents the harmful impact of free radicals, preserves the integrity of cell membranes, prolongs the duration of the electrical potential, prevents the activation of neutrophils in the ischemic zone, reduces the severity of ischemic myocardial damage.
Vastarel safety information
The tablets are taken orally. Those are not chewed but swallowed as the whole with a glass of water. Adults take one tablet a day, regardless of food intake. The duration of the course is determined by the healthcare provider. The combined treatment with heparin, acetylsalicylic acid, hypolipidemic medicines, calcium antagonists, vitamin K antagonists is acceptable.
Vastarel is contraindicated in children, pregnant and lactating women. This pharmaceutical is prohibited for use in patients with chronic renal failure. It is extremely cautious to use it in people with hepatic insufficiency, people of advanced age. It is not prescribed to patients with Parkinson's disease, with secondary parkinsonism. In the case of revealed excessive sensitivity to the components of the Vastarel formula, its administration is prohibited.
Vastarel side effects
In cases of an overdose, there is a manifestation of hypotension and hyperemia of the face. In general, in patients receivingVastarel tablets, there is a good tolerability of this medical remedy. Rarely, on the part of the digestive canal, there may be diarrheal disorders, abdominal pain, nausea, disturbances in the character of the stool. Infractions of the neurological sphere are manifested in the form of dizziness, cranialgia, discoordination, symptoms of extrapyramidal insufficiency, which may be stopped by the withdrawal of the medicine. In terms of cardiovascular reactions, the occurrence of arrhythmias is possible. On the part of the blood, Vastarel is sometimes accompanied by a decrease in the number of platelets, agranulocytosis. The intake of Vastarel can provoke the appearance of unwanted skin reactions in the form of an allergic rash, itching of the skin. Very rarely, a toxic hepatitis is possible. The asthenic syndrome is a common phenomenon.
Coumadin - anticoagulant of indirect action. It is taken for treatment and prevention of a deep vein thrombosis and embolism of a pulmonary artery, the transitory ischaemic attacks and an ischemic stroke, secondary prevention of myocardial infarction and prevention of tromboembolic episodes after a myocardial infarction, prevention of tromboembolic episodes at patients with fibrillation of auricles, cardiac valve damage or with the fitted prosthesis heart valves.
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An oral hypoglycemic means, which inhibiting the intestinal alpha-glycosidase, reduces the enzymatic conversion of di-, oligo - and polysaccharides to mono-saccharides, thereby reducing the absorption of glucose from the intestine and postprandial hyperglycemia. It is used to treat diabetes, of type 2 under the ineffective diet, the course of which shall not be less than 6 months, type 1diabetes within the combination therapy.
Blocks the final stage of HCl secretion, reducing basal and stimulated secretion, regardless of the nature of the stimulus. Prescribed for gastric ulcer and duodenal ulcer in acute phase, erosive-ulcerative esophagitis, reflux esophagitis, Zollinger-Ellison syndrome, stress ulcers of the gastrointestinal tract; eradication of Helicobacter pylori within a combination therapy, non-ulcer dyspepsia.
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