The drug dilates coronary vessels (mostly arterioles) and causes a significant increase in volumetric blood flow velocity. Increases the content of oxygen in venous blood of coronary sinus and its absorption by myocardium. Promotes the development of collateral coronary circulation, reduction in a systemic vascular resistance, improves microcirculation, has angioprotective action.
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Persantine product description
Persantine belongs to the group of drugs affecting the system of blood and blood formation in the human body. The composition includes Dipyridamole - a medical agent used in order to reduce coagulation. Dipyridamole was originally proposed as a coronary-extending (dilating heart vessels) antianginal (anti-anginal) medical preparation. According to experimental data, the drug expands coronary vessels (heart vessels), increases the volume rate of coronary (cardiac) blood flow, improves the supply of myocardium (cardiac muscle) with oxygen. Increases myocardial tolerance to hypoxia (cardiac muscle resistance to oxygen deficiency).
When the circulation in the main coronary vessels is disturbed, this pharmaceutical promotes an improvement in blood circulation in the collateral vasculature (along the blood vessels, by which blood flows around the affected vessel). Under its influence, the total peripheral resistance (total mechanical resistance to blood flow through the vessels) also decreases, the systemic blood pressure decreases somewhat, and cerebral circulation improves.
In the mechanism of the vasodilator effect of Dipyridamole, an increase in the formation of adenosine, one of the participants in the autoregulation of coronary blood flow (regulation by the heart of the rate of blood flow through its vessels) plays a significant role. Dipyridamole is a competitive inhibitor of adenosine deaminase, an enzyme that cleaves adenosine. As coronary dilatant, Dipyridamole is currently limited in use. It is sometimes used for chronic ischemic heart disease.
An important feature of Dipyridamole is its ability to inhibit aggregation (adhesion) of platelets and prevent the formation of clots (blood clots) in the vessels. The drug stimulates the biosynthesis (formation in the body) of prostacyclin and suppresses the synthesis of thromboxanes (biologically active substances taking part in the regulation of vascular tone and the coagulation system of blood).
Persantine safety information
This medical remedy is contraindicated in patients with the prevalent stenosing atherosclerosis of the coronary arteries (a disease of the heart vessels characterized by a decrease in their lumen), thrombocytopenia, intolerance of components, liver and kidney failure in severe form, hemorrhagic syndrome, arterial hypotension, subaortic stenosis of the aorta, cardiac decompensated insufficiency. It is forbidden to prescribe this medication to patients younger than 12 years.
Persantine side effects
According to anti-aggregation activity, Dipyridamole is inferior to Ticlopidine, close to Acetylsalicylic acid. At the same time, it is better tolerated than Acetylsalicylic acid, does not exert ulcerogenic (causing gastric ulcer) action. Dipyridamole is usually well tolerated. In some cases, short-term reddening of the face (vasodilator effect), increased pulse, allergic skin rash.
Flagyl - antiprotozoan and antimicrobic drug. It is prescribed at treatment of protozoan inspections (abenteric amebiasis, including amoebic abscess of liver, an intestinal amebiasis, trichomoniasis, giardiasis, balanthidiasis, lambliasis, skin leushmaniosis, mecotic vaginitis, mecotic urethritis), pseudomembranous colitis, gastritises, ulcer, prevention of postoperative complications (especially interventions at segmented intestine, perirectal area, appendectomy, gynecologic operations).
Cialis Super Active is a generic drug, against erectile dysfunction, containing 20 mg of tadalafil. The tablets in this series have a gel inside. This form allows the active substance, Tadalafil, to immediately enter the blood, thus providing an immediate effect. The result from the Cialis Super Active tablets appears after 5 minutes! The action lasts for two days. The drug is safe and has virtually no contraindications.
Viagra Soft Flavored - chewing tablet viagra, which has a mint taste and differs from usual viagra by mode of administration and speed of effect. Unlike usual viagra - Viagra Soft Flavored should be resolved or chewed. So at administration of drug it is possible to take alcohol and greasy food that is not recommended at taking of any other type of viagra. The effect of Viagra Soft Flavored comes in 30 minutes after reception, and lasts for 4 hours.
Floxin - antimicrobic broad-spectrum agent from group of fluroquinolone. It is active concerning the microorganisms producing beta lactamelements and fast-growing atypical mycobacteria. It is taken at respiratory infection, the ENT organs, skin, soft tissues, bones, joints, abdominal cavity, urinary tract.
An antiarrhythmic Ia class drug, a blocker of the "fast" Na+ channels. It has a membrane stabilizing, anti-arrhythmic, hypotensive and m-anticholinergic action. In normally functioning sinus node it causes acceleration of the sinus rhythm due to the antimuscarinic effect.
An antiparkinsonian agent. A non-ergoline selective agonist of dopamine D2 and D3 receptors. A possible mechanism of action in the treatment of Parkinson's disease , associated with a stimulating effect on the postsynaptic D2 receptors of the basal nuclei in the brain.
Avalide is an effective medicine which aim is to lower the blood pressure. Hypertension provokes serious diseases as strokes, heart attack, and problems with the kidney. An angiotensin receptor blocker and diuretic are the basic components of the drug. The first one relaxes the walls of the blood vessels letting the blood move freely without the pressure. The second component stimulates urination so that a patient can get rid of extra salt and water which also provoke high blood pressure.
The medicine belongs to the group of cardiac glycosides. The preparation obtained from the medicinal plants' Woolly Foxglove. It has the following actions: inotropic, vasodilator and moderate diuretic. The pills increase the concussive and systolic volume of the heart, increases the refractory period, reduces atrioventricular conduction, reduces the frequency of contractions of the heart muscle. In the case of stagnation in cardiovascular insufficiency, it has a pronounced vasodilating effect. Lanoxin has a mild diuretic effect, reduces the severity of edema. Overdosage may trigger an increase in the excitability of the myocardium, resulting in disturbances of heart rhythm.
Dapsone is a pharmaceutical antibiotic used for the treatment of symptoms related to severe skin conditions caused by bacterial infections. It decreases the swelling, among other symptoms in skin affected by dermatitis, and leprosy (Hansen’s disease). Each tablet contains 100mg of dapsone. The generic brand for this medication is: Aczone.
