The antifungal agent which has activity against dermatophytes, yeasts, dimorphic fungi and eumycetes. It is also active against staphylococci and streptococci. The therapeutical indications of the drug include: mycoses of the gastrointestinal tract, eyes, genital organs, chronic recurrent vaginal candidiasis, dermatomycosis, onychomycosis, Candida, folliculitis, dermatophytosis, systemic fungal infections (blastomycosis, candidiasis, paracoccidioides, coccidioidomycosis, cryptococcosis, histoplasmosis, hromomikoz, sporotrichosis, paronychia, fungal sepsis, fungal pneumonia); leishmaniasis; tinea versicolor, prevention of fungal infections in patients with a high risk of their development. The mechanism of action is inhibition of fungal membrane ergosterol synthesis and the violation of the cell wall permeability.
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Nizoral Product Description
Drug Uses
Nizoral is an antifungal agent used for the treatment of local and systemic fungal infections in children and adults. Indications for Nizoral use depend on the dosage form of Nizoral.
Topical Nizoral (cream, shampoo) is used to treat severe seborrhoeic eczema (seborrhoeic dermatitis) and severe tinea versicolor (pityriasis capitis, pityriasis versicolor) in patients aged 12 and older. In frequent relapses of seborrhea and (or) tinea versicolor, topical Nizoral can be used to prevent fungal scalp infections.
Oral Nizoral (tablets) is used to treat South American blastomycosis, valley fever, chromoblastomycosis, histoplasmosis, blastomycetic dermatitis and other systemic fungal diseases in children older than 2 years and adults.
High doses of Nizoral (1200 mg) are effective in treating Cushing's syndrome, but not approved for the treatment of this endocrine disorder, and can be administered to the patients with Cushing's syndrome only as "off-label".
Missed Dose
If you forget to take a dose of Nizoral, take it immediately when it is possible only if it is not almost time for the next dose of this antifungal agent. Then skip the missed dose and do not double the next dose of Nizoral to catch up the dose.
More Information
One the symptoms of tinea versicolor is skin pigmentation disorders characterized by the appearance of dark or discolored patches of skin, mostly on the trunk. Less commonly, pigmentation disorders extend to the skin of upper thighs, neck or arms. In regular use of topical Nizoral, the skin color gradually normalizes. However, the full restoration of normal skin color may take several months.
Storage
It is recommended to store Nizoral in a tightly closed package at temperature not above 30°C.
Keep Nizoral tablets out of the reach of children, as well as away from pets.
Nizoral Safety Information
Warnings
Oral Nizoral should be used only if alternative methods of treatment of systemic fungal infections are contraindicated or ineffective. Nizoral shampoo, cream or tablets may cause itching, rash or other symptoms of allergic reaction in some patients. If any signs and symptoms of allergy arise, the use of topical and oral Nizoral should be discontinued.
Disclaimer
The information about the fungal infections provided in this review of Nizoral tablets is of general nature and should not be used for replacement of medical treatment or advice of the primary care physician. The online pharmacy accepts no responsibility for any claim, loss or damage, suffered as a consequence of reliance on the information about this antifungal agent - Nizoral.
Nizoral Side Effects
Typically, Nizoral is easily tolerated by the body, so it does not cause any serious adverse effects. During the use of oral Nizoral, pruritus or gastrointestinal adverse effects, such as vomiting, dyspepsia and nausea most often arise. Less frequently, Nizoral may cause abdominal pain, rash, adrenal insufficiency or diarrhoea. This antifungal agent may cause hepatotoxicity, which does not depend on the drug dosage and disappears in a while after the discontinuation of Nizoral use.
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