Arava - a basic medicine with antirheumatic effect. Action is happened due to active metabolite of leflunomid. It has the inhibiting action on degidrorotate-dehydrogenase. Taking the medicine the progression of rheumatoid arthritis is slowed down, it is stopped the affection of arthral layers. Development of therapeutic effect is observed in a month. Increase of effect is noted within half a year.
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Arava product description
Drug uses
Arava is a pyrimidine synthesis inhibitor, used to treat symptoms of rheumatoid arthritis. The drug is characterized by anti-inflammatory, immunosuppressive and antiproliferative action, slowing progressive joint destruction in active rheumatoid arthritis.
Arava tablets are prescribed to adolescents above 18-year-old, adults and elderly patients for the treatment of:
- active psoriatic arthritis
- active rheumatoid arthritis
Treatment is usually recommended to begin with a single Arava dose of 100mg per day to be taken for three consecutive days. In therapy of rheumatoid arthritis and psoriatic arthritis, the maintaining dose of Arava is advised as 20mg per day.
Arava doses above 20mg /day are not recommended. In case of poor drug tolerability, the daily dose can be reduced to 10mg. Arava administration in elderly patients above 65 years does not require dosage adjustment. Typically, the therapeutic effect of Arava is observed in 4-5 weeks and can be further accumulated for up to 4-6 months.
Missed dose
If the patient has forgotten to take an Arava pill, it should be taken as soon as possible, unless it is not the time for the next dose of the drug. In case if it is the nearly time to take the next Arava pill, a missed dose is recommended to be skipped, and a succeeding dose to be taken as usual. Patients should not double-up on the next dose, otherwise allergic reactions or side effects may appear.
More information
Arava tablets are prescribed to be swallowed whole with plenty of water. The drug can be taken regardless of food, at the same time every day. During treatment, the patients are recommended to refrain from alcoholic beverages. Arava pills together with alcohol can adversely affect the patient’s liver state.
Storage
Pyrimidine synthesis inhibitor Arava should be stored at room temperature below 25°C in the original package to avoid moisture and light on pills. Do not store Arava in facilities like bathroom or kitchen, or accessible to children.
Arava safety information
Warnings
Arava is not recommended for pregnant women and breastfeeding mothers. The drug may increase blood pressure in some patients. Arava is contraindicated to patients with severe immunodeficiency states (e.g. AIDS), impairment of liver function, severe hypoproteinemia (e.g. in nephrotic syndrome), significantly impaired bone marrow function.
Coadministration of Arava with activated charcoal may lead to decrease in Arava efficacy. Live vaccines are not recommended to be administered in patients if they are taking Arava.The therapeutic efficacy of Arava can be affected by medications for asthma treatment (theophylline), muscle relaxant medicines (tizanidine), oral contraceptives, anti-inflammatory drugs (sulfasalazine, indometacin, ketoprofen), certain drugs for cancer treatment (daunorubicin, methotrexate).
Disclaimer
Review of immunomodulatory agent Arava is provided here solely for informational purposes. Information about Arava and antirheumatic therapy under no circumstances should be used instead of consultation with the immunologist or rheumatologist. In no event the online pharmacy shall not be liable for any loss or damage arising from the use or inability to use this review about Arava.
Arava side effects
Pyrimidine synthesis inhibitor Arava may cause some adverse reactions; usually they are expressed as nausea, leucopenia, weight loss, musculoskeletal disorder. Certain psychopathological disorders, expressed as asthenia, dizziness, headache, and gastrointestinal disturbances - diarrhea and dyspepsia can be observed as well.
Sometimes adverse reactions of Arava can be expressed as paraesthesia and skin disorders, such as mild allergic reactions or rash, and respiratory infections. In addition, hypertension and alopecia are rarely reported during the rheumatoid arthritis treatment with Arava pills.
Amaryl - a medicine of group of sulphonylurea, the peroral hypoglycemic medicine. It has an initially prolonged effect. The mechanism of action consists in stimulation of secretion and release of insulin from beta cells of a pancreas (pancreatic effect). It also increases sensitivity of fatty and muscular tissues to effect of insulin (extrapancreatic effect).
Cialis is a latest medicine for treatment of disturbances of erection at men. Cialis feature is its high-speed performance (30 minutes) and a long-term effect (up to 36 hours). In this regard you can choose the moment which is most suitable for sexual intercourse, having accepted a drug in advance. It is possible to take Cialis in the morning and to be ready even next day. Active ingredient - Tadalafil, the recommended dosage - 20 mg.
Viagra Professional - Advantage of Professional Viagra from usual Viagra is that it works twice longer (6 - 8 hours) and has a stronger effect. Strengthens desire, improves brightness of sexual feelings and increases duration of sexual intercourse.
Asacol, which is mesalamine - derivative of 5-aminosalicylic acid. It is prsecribed for treatment and remission maintenance at patients with ulcer colitis (earlier known as nonspecific ulcer colitis) of mild and moderate type.
Aygestin - the pharmaceutical preparation, containing synthetic analog of hormones of a yellow body of an ovary, it has a prominent effect on an internal cover of a uterus. It causes changes in an inside layer of a uterus, preparing it for implantation of an oospore, provides normal course of pregnancy, reduces contractility of a uterus, especially pregnant stimulates development of lactigerous parts of mammary glands. It is taken at treatment of a secondary amenorrhea, dysfunctional bleedings, polymenorrheas with the shortened phase of a yellow body, endometriosis, endometrial cancer, mastodynia and diffusion mastopathy.
Azulfidine - a medicine with antimicrobic and antiinflammatory properties. It is taken at ulcer colitis, an ulcer proctitis, a pseudorheumatism, Crohn's disease. After reception Sulfasalazinum - it is observed the normal intestinal microflora, and as result of the molecule of active ingredient breaks up to compound components: sulphapyridine and 5-aminosalicylic acid. These substances have antibacterial and antiinflammatory activity. Antiinflammatory effect of 5-aminosalicylic acid thanks to low ability to absorption is defined generally in walls of a large intestine. Sulphapyridine has generally systemic antiinflammatory effect due to better absorption.
Baclofen is a central muscle relaxant. It is assigned if the patient is diagnosed with spasticity in multiple sclerosis, strokes, craniocerebral trauma, meningitis, spinal diseases (infectious, degenerative, tumor and traumatic genesis), with infantile cerebral palsy; alcoholism
Benicar is a drug that is prescribed for essential arterial hypertension. In case of arterial hypertension, olmesartan causes a dose-dependent long-term reduction of a blood pressure.
Cozaar is used to treat arterial hypertension, protect the kidneys in type 2 diabetes mellitus with proteinuria, reduce the risk of associated cardiovascular diseases, as well as lower the death rate for hypertension, hypertrophy.
Danazol is used in endometriosis (with concomitant infertility), benign neoplasms of the breast (fibrocystic mastopathy), primary menorrhagia, premenstrual syndrome, primary premature puberty, gynecomastia.
Deltasone - renders an antiinflammatory, antiallergic, antishock and immunodepressive effect. It is taken for treatment of acute and chronic inflammatory diseases of joints, acute asthma, allergic diseases, skin diseases.
Eskalith - mood stabilizing agent (normalizes a mental state, without causing the general block), renders also antidepressive, sedative and anti-maniacal action. It is prescribed at maniacal and hypomaniacal states of various genesis, affective psychoses, alcoholism, migraine, Menyer's syndrome, sexual frustration, medicinal dependence.
Fights diarrhea (acute and chronic of various genesis: allergic, emotional, drug, radiation, with a change in diet and quality of food, in violation of metabolism and absorption), used for regulation of stool in patients with ileostomy. Loperamide (the effective ingredient of Imodium) reduces the tone and motility of the smooth muscles of the intestine. Slows down the peristalsis and increases the transit time of intestinal contents. Increases the tone of the anal sphincter, promotes retention of fecal masses and reduced urge to defecate. The effect develops quickly and lasts for 4-6 hours.
Kemadrin is a medicinal substance similar in its effect to atropine; It is used to reduce tremor and rigidity of muscles in Parkinsonism.
Cardioselective beta-1 blocker. Does not have a membrane-stabilizing action and does not have an internal AGR. Has antihypertensive, anti-angiogenic and antiarrhythmic action. It is used for IHD, angina pectoris, unstable angina, myocardial infarction, arterial hypertension, hypertensive crisis, tachycardia, thyrotoxicosis.
Nootropil improves cognitive processes, memory, attention, and mental performance.
Nootropilum affects the CNS, by changing the speed of propagation of the excitation in the brain, improves metabolic processes in nerve cells, improves by acting on the rheological characteristics of blood and causing no vasodilatory action.
Prometrium is used as part of hormone replacement therapy for women who underwent menopause (menopause) and did not have a hysterectomy (surgical removal of the uterus). Prometrium is also used to cause menstruation for women of childbearing age.
Seroquel - treats acute and chronic psychoses, including schizophrenia. The drug is also prescribed to patients with manic episodes associated with bipolar disorders.
Tenorminis a cardioselective beta-adrenoblocker. It is based on a substance called Atenolol, which blocks nerve impulses, which leads to a decrease in the frequency and strength of the heartbeat. Atenolol has antihypertensive (lowers pressure), antianginal (eliminates the symptoms of myocardial ischemia) and antiarrhythmic (eliminates heart rhythm disturbances) by action.
Teramycin acts depressingly on pathogens of many diseases, as well as biomycin. It is less toxic and longer preserves its action in the body. The medicine is used for the treatment of anthrax, teileriosis, cholera and pasteurellosis and other diseases.
Valtrex is an antiviral. The active substance - valaciclovir - penetrates into the affected cell, interacts with enzymes, is embedded in the DNA of the pathogen. It is active against Herpes Simplex, Cytomegalovirus, Varicella-Zoster, Epstein-Barr, HHV-6 (herpes simplex type 6).
Vasotec- an antihypertensive drug based on the action of the active ingredient Enalapril, whose mechanism of action is associated with inhibition of the activity of the angiotensin-converting enzyme, leading to a decrease in the formation of the vasoconstrictor factor - angiotensin II and simultaneously to the activation of the formation of kinin and prostacyclin possessing a vasodilating action.
Xenical - a powerful, specific and reversible inhibitor of gastrointestinal lipases, which has a long-lasting effect. Its therapeutic effect is carried out in the lumen of the stomach and small intestine and consists in the formation of a covalent bond with the active serine portion of the gastric and pancreatic lipases. The inactivated enzyme at the same time loses the ability to break down food fats coming in the form of triglycerides, to sucking free fatty acids and monoglycerides. Since uncleaved triglycerides are not absorbed, the resulting decrease in the intake of calories into the body leads to a decrease in body weight. Thus, the therapeutic effect of the drug is carried out without absorption into the systemic circulation.
Zantac - ranitidin - the drug is intended for the treatment of duodenal ulcers, benign gastric ulcer, postoperative ulcer, reflux esophagitis, Zollinger-Ellison syndrome, epigastric or chest pain. The administration of ranitidine is indicated in cases where a decrease in gastric secretion and a decrease in the production of hydrochloric acid is desirable, for the prevention of gastrointestinal bleeding, for the prevention of recurrence of bleeding in patients with bleeding ulcers of the stomach and duodenum, before general anesthesia in patients with a presumed risk of aspiration of acidic stomach contents (Mendelssohn syndrome), especially in women during childbirth delivery clashes.
Zocor is indicated to reduce mortality due to coronary artery disease. It is prescribed for the reduction of risk of serious vascular and coronary complications: non-fatal myocardial infarction, coronary death, stroke; revascularization operations. Designed to reduce the risk of the need for coronary blood flow restoration; rot reduce the risk of the need for surgical intervention to restore peripheral blood flow and other types of non-coronary revascularization; to reduce the risk of hospitalization in connection with attacks of angina pectoris; to decrease in the elevated level of total cholesterol, LDL cholesterol, triglycerides. apolipoprotein B; for increasing HDL cholesterol in patients with primary hypercholesterolemia, including heterozygous familial hypercholesterolemia.
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Elimite is a brand-name drug that has generic variants as Permethrin. It’s produced in the form of the topical agent. It’s a cream that kills parasites, head lice and Sarcoptesscabiei in particular. The drug first paralyzes and then kills parasites and exterminates their eggs. The cream can be used in pediatrics and by adults. It’s safe and is recommended to be removed in the bath or shower. People should remove it in eight to fourteen hours. Sometimes the treatment needs to be repeated.
FML (Fluorometholone) Forte is a topical drug that belongs to the corticosteroid group of medicines. Its aim is to cure various eye problems connected with injury and inflammation. It is effective in case of bulbar conjunctiva and palpebral conjunctiva. The suspension remedies eye swelling, itching, irritation, and redness. These eye drops are not recommended to people who wear contact lenses daily. If a patient must use the drops, it’s necessary to replace contact lenses with glasses or just not to wear them during the medication.
It has a direct influence on muscles, mainly of arterial vessels over nitric receptor situated in blood vessels. Its active component is transformed into oxide in smooth muscles that effect prompts the activity of guanylate cyclases. It is crucial for the creation of cyclic guanosine monophosphate (relaxation mediator). The drug influence the processes in the central vascular system and heart activity. The nature and force of the influence of nitroglycerin on the cardiac organ and vessels depend on the cooperation of essential actions.
The drug made of herbs is used in the treatment of varicose veins, thrombophlebitis, hemorrhoids, proctitis. Its active components reduce varicose veins and prevent their formation. In general, it has a healing effect on veins, improves blood circulation, strengthens the walls of venous vessels, relieves inflammation and swelling, reduces pressure in the venous system of the liver. Pilex has an anti-inflammatory effect on the nodes of the venous system, accelerates blood stagnation, lowers cholesterol, relieves discomfort, itching and pain as well as inflammation of the rectum, hemorrhoids.
Shallaki offers a herbal cure for sore joints and is based on an extract from Boswellia serrate. Completely natural origin of the medicine guarantees its safety and pure benefits for the body. It is a powerful auxiliary remedy applied in the treatment of arthritis as well as prevention of joint conditions. Shallaki alleviates pain and swelling in areas of inflammation and lowers the overall level of triglyceride and cholesterol with high efficiency. Its health-promoting behavior makes it a great aid for weight reduction.
Zyvox is a synthetic medicine with the increased antibacterial effectiveness. It is mostly used in the treatment of pulmonary and skin diseases caused by a wide range of Gram-positive species. In current medicinal practice, Zyvox often plays a role of the drug of last resort, since it is intended for use in people suffering from multidrug-resistant infections. The extremely high efficiency of this medicine makes it a popular choice in the treatment of severe bacterial infections and simultaneously limits its use against low-hazard infections in order to avoid propagation of resistant microorganisms.
Zyprexa is an antipsychotic drug used mainly to treat severe mental conditions, most notably schizophrenia. This oral medication normalizes the balance of chemical compounds in the brain, especially when used in combination with other antipsychotics. The active ingredient, which is a ligand for serotonin and dopamine receptors, provides also a selective impact on the functioning of the limbic system. The target group of the drug is not limited to the cases with extra severity – the pills may be prescribed for people with moderate mood or nervous conditions as well.
Valif is a substitute drug for Levitra, with the active ingredient vardenafil, which treats the symptoms of erectile dysfunction or impotence in men and increases libido in women.
Product description
Alfacip is an active metabolite of Alfacip, which performs important functions in regulation of the calcium balance and the bone metabolism. (Hypocalcemia; Osteodystrophy; secondary hyperparathyroidism;)