Cordarone - antiarrhytmic drug of III class (repolarization inhibitor). Possesses also anti-anginal, coronarodilator, alpha and beta, adrenoceptor blocking and hypotensive action. The anti-anginal effect of Cordarone is caused by coronarodilator and anti-adrenergic action, reduction of need of a myocardium for oxygen.
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Cordarone Product Description
Drug Uses
Cordarone is a long-acting antiarrhythmic agent providing an antianginal effect and increasing blood flow in the myocardium. Cordarone is prescribed to patients with heart diseases, associated with diminished function of the atria and ventricles.
Cordarone helps to quickly reduce symptoms of different types of (paroxysmal) irregular heartbeat:
Atrial fibrillation, including asymptomatic
Serious rhythm disturbances (eg, WPW syndrome)
To stabilize the heart rate, high doses of Cordarone should be taken first, and then, reduced gradually. In the first 10-20 days of antiarrhythmic therapy, dosage of Cordarone varies from 600 to 1600mg per day in several spaced doses.
Missed Dose
If you’ve forgotten to take Cordarone, you can take the required dose of your antiarrhythmic drug as soon as you remember, but not later than 4 hours after the missed dose. If over 4 hours passed after the missed dose of Cordarone, take the next dose of the antiarrhythmic agent at the next scheduled time.
More Information
Based on the therapeutics response, Cordarone dosage should be gradually reduced to one 200mg pill of Cordarone, once or twice a day. Higher daily doses should be reasonably indicated and regularly adjusted.
Storage
Antiarrhythmic drug Cordarone should be stored in an original package, tightly closed and protected from light, at controlled temperature, no higher than 30°C, in a dry place.
Cordarone Safety Information
Warnings
Patients with diseases of the brain or spinal cord, hormonal disorders, photophobia, endocrine dysfunction, or optical nephritis should apply Cordarone with caution.
Disclaimer
Contents of this review of Cordarone are intended to represent common information on the treatment of cardiovascular diseases. This information shall not be considered as a substitution or alternative for professional medical treatment by cardiologists and cardiac specialists. The online pharmacy shall not be responsible for the use of any and all information about antiarrhythmic therapy and Cordarone.
Cordarone Side Effects
High doses of Cordarone may cause anorexia, fatigue, vomiting, and poor coordination, nausea, tremor, constipation, malaise, or gait. The risk of adverse effects is reduced, if medium or the lowest doses of Cordarone are used. When Cordarone supports the combination antiarrhythmic therapy, the risk of adverse effects is increased.
Serious adverse effects, which may require Cordarone application to be ceased, are reported as very rare ones. The results of investigations of the antiarrhythmic agent have demonstrated that withdrawal of Cordarone due to serious adverse effects (including hyperthyroidism, heart failure, hypothyroidism, solar dermatitis, or visual disturbances) was required for under 5% of patients.
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BCCC; a derivative of diphenylalkylamine. Has antianginal, anti-arrhythmic and hypotensive effect. The antianginal effect is associated with both direct action on the myocardium and with the effect on peripheral hemodynamics. It is prescribed with stenocardia, supraventricular tachycardia, sinus tachycardia, ciliary tachyarrhythmia, atrial flutter, atrial extrasystole, arterial hypertension, GOKMP, primary hypertension in the "small" circle of the circulation.
Anticholinesterase agent; having a cholinesterase effect through a reversible acetylcholinesterase inhibition and enhancing the action of acetylcholine. Improves neuromuscular transmission, increases the motility of the gastrointestinal tract, increases the tone of urinary bladder, bronchi, the secretion of exocrine glands. Prescribed for myasthenia gravis, postoperative intestinal atony, atonic constipation, bladder atony, post-traumatic movement disorders; flaccid paralysis; residual explication of polio, encephalitis, violation of emptying the bladder after gynecological surgery and childbirth.
Antidepressant. Strengthens the central adrenergic and serotonergic transfer. Used for the treatment of depressions including anhedonia, psychomotor retardation, insomnia, early awakening, weight loss, loss of interest in life, suicidal thoughts and mood swings.
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