Clozaril - atypical antipsychotic medicine. Blocks dopamine receptors of CNS and interferes dopamine transfer in basal gangliya and in limbic part of neoncephalon. It is taken at Hypersensitivity, diseases of hemopoietic system (including in anamnesis), alcoholic and toxic psychosis, myasthenia, comas.
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Clozaril Product Description
Drug Uses
Clozaril is an atypical antipsychotic agent, providing sedative, antipsychotic, antihistamine and anticholinergic effects. Clozaril is indicated to teenagers aged 18 years and above, adults and elderly patients for treatment of:
treatment-resistant schizophrenia
psychosis during the course of Parkinson's disease
suicidal behavior in patients with schizophrenia or schizoaffective disorder
Clozaril benefits are that the drug does not virtually cause any extrapyramidal side effects such as akathisia, dystonia, bradykinesia and tremor, like other antypsyshotics do.
In contrast to classic antipsychotics, Clozaril does not increase at all or insignificantly increases the level of prolactin. Because of this, such side effects as galactorrhea, gynaecomastia and amenorrhea are normally avoided during the antipsychotic treatment with Clozaril.
To treat mental disorders, a therapeutic dose of Clozaril is recommended to be adjusted individually. At the beginning of antipsychotic therapy, low doses of Clozaril are most effective ones. For the treatment of severe mental diseases, the maximum daily Clozaril dose of 900mg can be indicated. But Clozaril doses above 450mg may significantly increase the risk of seizures and other side effects.
Missed dose
Under no circumstances should the prescribed dose of Clozaril be increased or decreased. It is stricktly not recommended to interrupt Clozaril application for more than 2 days. If you’ve forgotten to take Clozaril tablets, take the missed dose of this antipsychotic drug as soon as you remember. However, if it is nearly the time for the next prescribed dose, do not take an extra antipsychotic pill to make up the missed dose of Clozaril.
More Information
Sudden cessation of the intake of the antypsyshotic drug may cause withdrawal symptom and adverse reactions. If treatment is required to be immediately terminated (for example, in case of developing eosinophilia), gradual reduction of Clozaril dose and careful observance for the patient's mental state are recommended. Patients 60 year old and above should start the antipsychotic treatment with very low doses of Clozaril, and gradually increase the daily dose, not more than by 25mg per day.
Storage
Store the Clozaril tablets in an original container to protect them from heat and moisture. Keep Clozaril out of the reach of children at temperature not above 30°C.
Clozaril Safety Information
Warnings
During the treatment with Clozaril, severe neutropenia (abnormally low count of neutrophils) may develop in some patients, resulting in complex infection. High risk of neutropenia is observed in the first days of the antipsychotic therapy, and then is gradually decreased. Clozaril may increase the risk of seizures, so epileptic patients should take the antipsychotic with caution.
Disclaimer
Information about psychotic diseases, contained in the review of Clozaril, is
provided for the informational purposes only and should not be considered to
substitute for qualified medical care or advice of the health care provider.
The online pharmacy does not assume any liability or responsibility for damage,
arising from any use of information on atypical antipsychotic agent Clozaril.
Clozaril Side Effects
Most adverse effects of Clozaril appear only at the beginning of the antipsychotic therapy and eventually disappear. The most frequent and serious adverse effects, which Clozaril may cause include: leukocytopenia, somnolence, dizziness and psychotic disorder. Other common adverse effects of antipsychotic agent Clozaril are reported as: granulopenia, seizure triggers, cardiovascular effects, fever drowsiness/sedation, dizziness, tachyarrhythmia, constipation and ptyalism.
Abilify is designed for patients with diagnosis named schizophrenia. It is used either during the exacerbation period or for maintenance treatment. Abilify is also prescribed in cases of an acute manic episodes of type 1 in manic-depressive psychosis, and as a supportive treatment for bipolar affective disorders. Abilify can be used as an additional treatment during depressive disorders. According to some experts, the drug can be used in order to treat alcoholism.
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Aristocort - glucocorticoid drug (the adrenal hormone influencing carbohydrate and protein metabolism). Renders prominent antiinflammatory, antiallergic and immunodepressive (suppressing immunity - body defences of an organism) effect. It is prescribed at rheumatism, allergic reactions, multiform erythema (variously proceeding skin disease which occurs with rubefaction of affected area of skin), pseudorheumatism (the infectious and allergic disease from a group of collagenoses which is characterized by chronic progressing inflammation of joints); systemic lupus erythematosus and other collagenoses.
Cefadroxil - cephalosporin antibiotic of the I generation for intake. It works as bactericidal, breaking synthesis of a cell wall of microorganisms. It has a broad spectrum of activity: it is active in relation as gram-positive (Staphylococcus spp. which don't produce and produce a penicillinase; Streptococcus spp. (including Streptococcus pneumoniae), Corynebacterium diphtheriae, Bacillus anthracis), and gram-negative microorganisms (Shigella spp., Salmonella spp., Escherichia coli, Haemophilus influenzae, Klebsiella spp., some strains of Proteus spp., especially Proteus mirabilis), Moraxella catarrhalis (Branhamella). Many strains of Enterococcus faecalis and Enterococcus faecium are steady against Cefadroxil.
Cefixime is a medicine intended for the treatment of acute and chronic bronchitis, bacterial bronchitis, middle ear inflammation, pharyngitis and tonsillitis, bacterial infections of the urinary tract, cystitis, urethritis, pyelonephritis, cerivitis.
Exforge the combined antihypertensive which includes amlodipine and valastran. Valsartan - a specific blocker of AT1 receptors of angiotensin II. Amlodipin - calcium channel blocking agents of III generation, inhibits transmembrane receipt of Ca2+ in cardiomyocytes and smooth muscle cells of vessels, by weakening them.
The antibiotic produced by Streptomyces lincolniensis, has a bacteriostatic effect. Suppresses protein synthesis of bacteria due to reversible binding to the 50S subunit of ribosomes, disrupts the formation of peptide bonds.
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Strattera - the drug with an international non-proprietary name of the active substance - Atomoxetine, it is intended as a sympathomimetic agent for the prevention and treatment of attention deficit hyperactivity disorder (ADHD) in children 6 years of age and older, adolescents and adults.
Teramycin acts depressingly on pathogens of many diseases, as well as biomycin. It is less toxic and longer preserves its action in the body. The medicine is used for the treatment of anthrax, teileriosis, cholera and pasteurellosis and other diseases.
Theo-24 Cr - medication with an active ingredient called Theophylline, the brand of Pfizer and UCB Pharma. The drug is prescribed for treatment of bronchial asthma, chronic obstructive bronchitis, pulmonary emphysema, pulmonary hypertension, pulmonary heart, edematous renal syndrome (as part of a combination therapy), nocturnal apnea.
Trimox has an active ingredient called amoxicillin. It is an antibiotic of penicillin, which fights bacteria. Trimox is used to treat many different types of infection caused by bacteria such as tonsillitis, bronchitis, pneumonia, gonorrhea and infections of the ear, nose, throat, skin or urinary tract. This remedy is sometimes used together with another antibiotic called clarithromycin (Biaxin) to treat stomach ulcers caused by Helicobacter pylori infection. This combination is sometimes used with a gastric acid reducer, called lansoprazole (Prevacid).
Zithromax - antibiotic of a wide spectrum of action. Antibiotic-azalide, a representative of a new subgroup of macrolide antibiotics. In the focus of inflammation it has a bactericidal effect. For the active ingredient of Zithromax, Azithromycin, all the gram-positive cocci (except those bacteria which are resistant to erythromycin) are susceptible.
Zocor is indicated to reduce mortality due to coronary artery disease. It is prescribed for the reduction of risk of serious vascular and coronary complications: non-fatal myocardial infarction, coronary death, stroke; revascularization operations. Designed to reduce the risk of the need for coronary blood flow restoration; rot reduce the risk of the need for surgical intervention to restore peripheral blood flow and other types of non-coronary revascularization; to reduce the risk of hospitalization in connection with attacks of angina pectoris; to decrease in the elevated level of total cholesterol, LDL cholesterol, triglycerides. apolipoprotein B; for increasing HDL cholesterol in patients with primary hypercholesterolemia, including heterozygous familial hypercholesterolemia.
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It has a direct influence on muscles, mainly of arterial vessels over nitric receptor situated in blood vessels. Its active component is transformed into oxide in smooth muscles that effect prompts the activity of guanylate cyclases. It is crucial for the creation of cyclic guanosine monophosphate (relaxation mediator). The drug influence the processes in the central vascular system and heart activity. The nature and force of the influence of nitroglycerin on the cardiac organ and vessels depend on the cooperation of essential actions.
Cefaclor is a medicine used to treat the symptoms of various bacterial infections such as Bronchitis, Pharyngitis and Tonsillitis, Urinary Tract Infection, Ear Infections (Otitis Media) and Lower Respiratory Tract Infections. Cefaclor may be used alone or with other medications.