Peripheral vasodilator with predominant effect on venous vessels. Reduces the need for myocardium in oxygen by reducing preload and afterload (reduces the end diastolic volume of the LV and reduces the systolic tension of its walls). Has the coronary dilatation effect. Reduces blood flow to the right atrium, helps to reduce pressure in the "small" circle of blood circulation and regression of symptoms with pulmonary edema. Promotes redistribution of coronary blood flow in the area with reduced blood circulation. Increases tolerance to physical activity in patients with IHD, angina pectoris.
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Isordil product description
Isordil is the venous, as well as the arterial dilator, which lessens the necessity for myocardium in oxygen, prior and afterload on the heart, has a coronary expansive effect, stabilizes the pressure in a small circle of blood supply, reduces the stress of the walls of the ventricles. Raises the number of the content of nitric oxide in the tissues of blood vessels. The preparation is prescribed during the recovery therapy after myocardial infarction, with the elimination and prevention of angina attacks.
Isordil safety information
Among the restrictions to the remedy usage, there are allergic reactions to the components of the medical remedy, severe arterial hypotension, hyperthyroidism, acute vascular insufficiency, cardiogenic shock, an angle-closure form of glaucoma, age under 18 years (efficacy and safety not established). Pregnant and breastfeeding women should consume Isordil very carefully, only in extreme cases at the urging of a physician.
Special caution should be exercised if the patient has cardiac tamponade and constrictive pericarditis, aortic and/or mitral stenosis, hypertrophic obstructive cardiomyopathy, a tendency to orthostatic reactions (a sharp reduction in blood pressure when the position of the body changes), severe renal failure, hepatic impairment (risk of methaemoglobinaemia) , maladies that are accompanied by increased intracranial pressure (including hemorrhagic stroke, craniocerebral injury), elderly age.
Isordil side effects
At the first consumption or increase in the dosage leads to a decrease in blood pressure, orthostatic hypotension, which can be accompanied by a reflex acceleration in heart rate, inhibition, as well as a sense of weakness and dizziness. At the very beginning of the therapy, the headaches may also appear, which, as a rule, disappear with further consumption of the remedy. There may be a feeling of the slight burning of the tongue, dry mouth. Rarely, nausea, retching, reddening of the face, fever and allergic skin reactions may manifest. In extremely rare cases with a strong reduction in blood pressure, there may be a paradoxical intensification of angina attacks and collapse, sometimes with bradycardia (slowing of heart rate) and syncope (fits with dizziness, associated with cerebral circulatory disorders due to rhythm disturbances heart, primarily due to a significant decrease in the rhythm of the heart). In some cases, exfoliative dermatitis (skin inflammatory disease) may manifest.
Accutane, which is isotretinoin, - is a form of vitamin A, belongs to the group of retinoids. It is often used to treat complex, neglected forms of acne, when the remaining anti-acne drugs do not have a positive effect on the treatment of acne. Accutane inhibits the production of sebum and reduces the size of the gums with the main active substance isotretinoin. It is proved that isotretinoin has an antiseptic effect. Also, isotretinoin thinens the stratum corneum of the epidermis to more easily penetrate deep into the affected area. Due to the fact that Accutane suppresses the sebum secretion by reducing the sebaceous glands themselves, this allows to reduce the migration of bacteria in the ducts. And due to the fact that the stratum corneum is thin, the skin fat has an outlet to the outside, from which there is no blockage of the pores and, as a result, pimples.
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Zestril is an angiotensin-converting enzyme inhibitor (ACE). It works by relaxing the blood vessels. This helps lower blood pressure. It is used in the treatment of high blood pressure, alone or in conjunction with other medicines.