Hyzaar - complex hypertensia medicine. A hydrochlorothiazide - Thiazide diuretic of average force and losartan - hypotensive drug which is specific blocker angiotensin II (AT1 type) of receptors. Does not suppress a kinase II - enzyme destroying bradykinin.
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Hyzaar Product Description
Drug Uses
Hyzaar is a medicine to treat high blood pressure and reduce the risk of cardiovascular events in patients with:
- mild, moderate and severe hypertension
- hypertension and left ventricular hypertrophy (LVH)
Hyzaar is a combined antihypertensive agent, which contains two active ingredients:
- Losartan (thiazide diuretic)
- Hydrochlorothiazide (angiotensin II receptor antagonist)
Patients with severe hypertension may use Hyzaar tablets for initial antihypertensive therapy. Hyzaar should be prescribed to patients with mild to moderate essential hypertension only if Hydrochlorothiazide monotherapy or Losartan monotherapy does not provide a sustained antihypertensive effect.
The minimal daily dose of Hyzaar is 50 /12.5 mg. Within a few weeks, Hyzaar dose can be gradually increased to 100/25 mg per day. Hyzaar dosage should not be increased earlier than 3 weeks after the start of combination antihypertensive therapy.
Missed dose
If the prescribed daily dose of Hyzaar is missed, resume the usual schedule of this antihypertensive agent on the next day. Do not take two doses of Hyzaar and extra antihypertensives to make up the missed dose.
More Information
If you failed to achieve a sustained antihypertensive effect 3-6 weeks after the start of using Hyzaar tablets, other medicines to lower high blood pressure can be included in the drug therapy.
Storage
Hyzaar tablets should be protected from excessive moisture and direct sunlight and stored in its original sealed packaging, at room temperature not exceeding 30°C.
Hyzaar Safety Information
Warnings
When using Hyzaar to reduce high blood pressure during pregnancy, this anti-hypertensive medicine may cause potentially dangerous influence on normal growth and development of the fetus. Therefore, pregnant women should refrain from using Hyzaar. If you become pregnant after the start of combination antihypertensive therapy, the use of Hyzaar pills should be discontinued immediately.
Disclaimer
Information about hypertension and cardiovascular risks provided in Hyzaar review is intended to be useful and informative. The information about Hyzaar should not be considered as a substitute for the medical advice of a cardiologist or consultation with a qualified medical professional. The online pharmacy expressly disclaims responsibility for any damage or any action, which can be caused by the use of information about Hyzaar antihypertensive medicine.
Hyzaar Side Effects
After Hyzaar use, most adverse events are mild and quickly disappear in prolonged therapy. According to statistics, only 2% of patients taking angiotensin stop using Hyzaar because of the following adverse events: dizziness, headache, upper respiratory infection, cough, and back pain. Less than 1% of patients taking Hyzaar experience such adverse events as dry mouth, weakness, somnolence, vertigo, nosebleeds, chest pain, irregular heartbeat, malaise, rash, excessive sweating, blurred vision, and dropsy.
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A receptors blocker angiotensin II (AT1 type). Has a vasodilating and hypotensive effect. Does not show the properties of the agonist of angiotensin receptors, does not affect the state of ionic channels involved in the regulation of SSS. Does not inhibit ACE. Decreases both systolic and diastolic blood pressure without affecting the pulse rate. The start of antihypertensive action is in 3 hours, a steady decrease of the blood pressure is in 4 weeks after the start of the treatment. The duration of the hypotensive effect after a single intake is 24 hours.
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The drug is an inhibitor of the enzyme peptidyl. It inhibits the angiotensin-converting enzyme, which catalyzes the conversion of angiotensin I to vasoconstrictor peptide angiotensin II. Angiotensin II also stimulates the secretion of aldosterone by the adrenal cortex. Inhibition of ACE leads to reduced concentrations of angiotensin II, resulting in low aldosterone secretion. The decrease in the latter leads to an increase in the content of potassium in the blood serum. Since the mechanism is believed to be based on the inhibition of the renin-angiotensin-aldosterone system, it reduces blood pressure even in patients with hypertension with low renin levels.
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