The drug is an inhibitor of the enzyme peptidyl. It inhibits the angiotensin-converting enzyme, which catalyzes the conversion of angiotensin I to vasoconstrictor peptide angiotensin II. Angiotensin II also stimulates the secretion of aldosterone by the adrenal cortex. Inhibition of ACE leads to reduced concentrations of angiotensin II, resulting in low aldosterone secretion. The decrease in the latter leads to an increase in the content of potassium in the blood serum. Since the mechanism is believed to be based on the inhibition of the renin-angiotensin-aldosterone system, it reduces blood pressure even in patients with hypertension with low renin levels.
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The tablets are aimed at normalizing blood plasma composition. They reduce triglyceride content and increase apolipoprotein AI. The medicine inhibits peripheral lipolysis, helps to remove free fatty acids from the liver and blocks the inclusion of acyl in synthesized triglycerides. They lower its levels in the liver.
Product Description
The pills make faster turnover and removal of cholesterol and promote its excretion from the body. The components of the remedy are well absorbed if you take it inside. Absorption occurs one and a half hours after administration. The tablets are low-toxic and they make a concentration of lipids in the blood lower. They decrease lipoprotein in patients with hypertriglyceridemia and increase the number of triglycerides in the blood.
The drug does not react to the treatment by diet or other hypolipidemic agents. It increases the concentration of HDL (high-density lipoproteins).The medicine is prescribed for patients with hypertriglyceridemia if they are resistant to a therapeutic diet or other related means. If one has hyperchylomicronemia (increased blood levels of chylomicrons /neutral fat particles with a diameter of 1 micron due to family deficiency of lipoprotein lipase (an enzyme that destroys lipoproteins), the drug will be ineffective.
Safety Information
It is necessary to check the number of lipids in the blood during the treatment. If the effectiveness of the drugs is not manifested within three months, then the therapy should be stopped. It is also necessary to follow the diet. In long-term care one needs a constant control of the peripheral blood and as well as of indications of the functions of the liver. If there are significant changes in the liver, it is necessary to stop treatment until the normal findings.
If you miss a dose of pills you need to take the next one as soon as possible and double it twice. Sometimes the pain in the muscles may appear and in this case, it is necessary to exclude the presence of myositis. If it is found in the body, the treatment will be canceled. One should stop taking pills if cholelithiasis is detected. The tablets are incompatible with lovastatin because there may be a severe form of myopathy or liver failure. The drug enhances the effect of indirect anticoagulants and oral hypoglycemic drugs.
While taking the drugs, the risk of violations of fat metabolism increases. Adult patients have prescribed pills of 0.45 grams twice a day. It is usually taken in the morning 30 minutes before breakfast or in the evening and 30 minutes before dinner. The highest therapeutic effect is observed after three or four weeks after the first administration of the tablet.
Side Effects
The medicine has an adverse reaction on the nervous system. One may feel the following symptoms:
- dizziness;
- a headache;
- excessive fatigue;
- drowsiness;
- depression.
Sometimes there is dysfunction in the digestive system, such as dry mouth, low appetite, nausea, vomiting, heartburn, constipation or diarrhea. On the part of the human motor system can there are:
- Myasthenia gravis;
- Myalgia;
- Arthralgia;
- Rhabdomyolysis.
In the genitourinary system, there are decreases in potency and libido. Sometimes there are allergic reactions that appear in the skin, for example, rash or dermatitis. Among other sideway actions, one can identify visual impairment, hypokalemia, alopecia, synovitis.
Etodolac - has an anti-inflammatory, analgesic, antipyretic effect. The medicine is prescribed in case of rheumatoid arthritis, ankylosing spondylitis, arthrosis with pain syndrome and restriction of movements, acute and chronic osteoarthritis.
Cialis is a latest medicine for treatment of disturbances of erection at men. Cialis feature is its high-speed performance (30 minutes) and a long-term effect (up to 36 hours). In this regard you can choose the moment which is most suitable for sexual intercourse, having accepted a drug in advance. It is possible to take Cialis in the morning and to be ready even next day. Active ingredient - Tadalafil, the recommended dosage - 20 mg.
Viagra Professional - Advantage of Professional Viagra from usual Viagra is that it works twice longer (6 - 8 hours) and has a stronger effect. Strengthens desire, improves brightness of sexual feelings and increases duration of sexual intercourse.
Topamax - the remedy with an active ingredient: topiramate, it is used as a monotherapy for the treatment of adults and children 6 years of age with partial attacks with or without secondary generalized seizures and primary generalized tonic-clonic seizures; as an adjunct therapy for the treatment of adults and children 2 years of age with partial attacks with or without secondary generalized seizures or primary generalized tonic-clonic seizures and the treatment of attacks associated with Lennox-Gasto syndrome; to prevent migraine attacks in adults, after careful evaluation of alternative treatment options. Topiramate is not recommended for the treatment of acute conditions.
Zocor is indicated to reduce mortality due to coronary artery disease. It is prescribed for the reduction of risk of serious vascular and coronary complications: non-fatal myocardial infarction, coronary death, stroke; revascularization operations. Designed to reduce the risk of the need for coronary blood flow restoration; rot reduce the risk of the need for surgical intervention to restore peripheral blood flow and other types of non-coronary revascularization; to reduce the risk of hospitalization in connection with attacks of angina pectoris; to decrease in the elevated level of total cholesterol, LDL cholesterol, triglycerides. apolipoprotein B; for increasing HDL cholesterol in patients with primary hypercholesterolemia, including heterozygous familial hypercholesterolemia.
The drug made of herbs is used in the treatment of varicose veins, thrombophlebitis, hemorrhoids, proctitis. Its active components reduce varicose veins and prevent their formation. In general, it has a healing effect on veins, improves blood circulation, strengthens the walls of venous vessels, relieves inflammation and swelling, reduces pressure in the venous system of the liver. Pilex has an anti-inflammatory effect on the nodes of the venous system, accelerates blood stagnation, lowers cholesterol, relieves discomfort, itching and pain as well as inflammation of the rectum, hemorrhoids.
