Cardizem, derivative benzothiazepine, has anti-anginal, antiarrhytmic and hypotensive effect. It is prescribed at arterial hypertension: after myocardial infarction, at patients with accompanying stenocardia when beta adrenoblockers, are contraindicative at patients with diabetic nephropathy, in cases when ACE inhibitors are contraindicated; angina of effort, Prinzmetal's angina; prevention of a coronary spasm when carrying out a coronary angiography or operation of aortocoronary shunting.

Cardizem ER - extended release tablets with diltiazem. Antiarrhytmic action is caused by learned suppression of transport of Ca2+ in heart tissues that leads to lengthening of the effective refractory period and delay of carrying out in AV nodosity. Hypotensive action is caused by dilatation of resistive vessels and decrease in TPR. Extent of decrease in arterial blood pressure is correlated with its initial level. It has the minimum influence on smooth muscles of GIT. During long (8 months) therapies tolerance does not develop.

Diltiazem - has anti-anginal, antiarrhytmic and hypotensive effects. Reduces the intracellular maintenance of Ca2+ in cardiomyocytes and cells of smooth muscles of blood vessels, reduces heart rate, shows insignificant negative inotropic effect, improves a coronary, brain and renal blood flow.