Anti-migraine drug. Specific and selective agonist of 5-HT1-serotonin receptors, localized predominantly in the blood vessels of the brain and it does not affect other subtypes of 5-HT-serotonin receptors (5-HT2-7). Causes narrowing of the vessels of the carotid arterial bed, that supply extracranial and intracranial tissues with blood (vasodilation of the meninges and / or their edema is the main mechanism of migraine development in humans) without significantly affecting cerebral blood flow.

Zoloft is an antidepresant stopping the reuptake of serotonin, which is performed by the neurons that isolated it. As a result, the concentration of the neurotransmitter increases in the synaptic cleft and the main cause of depressive states, the serotonin deficiency, is eliminated.